货品编号Bioss.bs-1402R

品牌Bioss

品名Anti-SREBP1胆固醇调节元件结合蛋白1抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Sheep,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量54/126kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human SREBP-1:301-450/1147

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer

flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is

synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following

cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1.

Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing

transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor

family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants

encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]