货品编号Bioss.bs-1640R

品牌Bioss

品名Anti-phospho-JNK1 + 2 + 3 (Thr183+Tyr185)磷酸化氨基末端激酶1/2/3抗体

规格100ul

研究领域肿瘤 免疫学 信号转导 转录调节因子

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量42kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated Synthesised phosphopeptide derived from human JNK1 around the phosphorylation site of Thr183/Tyr185:MM(p-T)P(p-Y)VV

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍JNK1 (MAPK8) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical

signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation

and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates

immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha

(TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced

apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of

this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced

transcript variants encoding distinct isoforms have been reported. JNK1 is activated by threonine and tyrosine phosphorylation

by either of two dual specificity kinases, MAP2K4 and MAP2K7. The JNK pathway is critically involved in diabetes and levels are

abnormally elevated in obesity. The cell-permeable JNK inhibitory peptide may have promise as a therapeutic agent for diabetes.