货品编号： Bioss.bsm-33051M 品 牌： Bioss 品 名：Anti-C-erbB-2/HER2HER2单克隆抗体 规 格： 100ul 研究领域 肿瘤免疫学信号转导激酶和磷酸酶 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 13H9 交叉反应 Human,Mouse,Rat, 产品应用 WB=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 138kDa 细胞定位 细胞核细胞浆细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 Recombinant human HER2 protein:full length 亚型 IgG 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.

This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does

bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding

and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-

activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655

of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655,

shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including

breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding

different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].