货品编号： Bioss.bsm-33052M 品 牌： Bioss 品 名：Anti-CD45白细胞共同抗原CD45单克隆抗体 规 格： 100ul 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 14A9 交叉反应 Human, 产品应用 WB=1:500-1000ELISA=1:1000-5000IHC-P=1:100-500IHC-F=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 143kDa 细胞定位 细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 Recombinant human CD45: 亚型 IgG1 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be

signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and

oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem

intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic

cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through

either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required

for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor

signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.