货品编号： Bioss.bsm-33190M 品 牌： Bioss 品 名：Anti-Caspase 8半胱氨酸蛋白酶8单克隆抗体 规 格： 100ul 研究领域 细胞生物神经生物学细胞凋亡 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 4G12 交叉反应 Human,Mouse,Rat, 产品应用 WB=1:2000-5000ELISA=1:500-1000IHC-P=1:400-1000IHC-F=1:500-1000ICC=1:100-500IF=1:500-1000（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 43/57kDa 细胞定位 细胞浆 性状 Liquid 浓度 1mg/ml 免疫原 Recombinant human Caspase 8 Protein : 亚型 IgG 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases

have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor

cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such

as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn

cause cell collapse.