货品编号： Bioss.bsm-33194M 品 牌： Bioss 品 名：Anti-Beta cateninβ-连环蛋白/β-连环素/β链接素单克隆抗体 规 格： 100ul 研究领域 肿瘤细胞生物信号转导细胞凋亡 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 6H4 交叉反应 Human,Mouse,Rat, 产品应用 WB=1:500-1000IHC-P=1:500-1000IHC-F=1:500-1000ICC=1:100-500IF=1:500-1000（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 92kDa 细胞定位 细胞浆细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 Recombinant human Beta catenin: 亚型 IgG 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary

for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded

protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells

to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated

in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR),

medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.