货品编号： Bioss.bsm-33218M-100ul 品 牌： Bioss 品 名：Anti-STAT3信号转导和转录激活因子3单克隆抗体 规 格： 100ul 研究领域 肿瘤细胞生物信号转导细胞凋亡转录调节因子 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 3F5 交叉反应 Human,Mouse,Rat, 产品应用 WB=1:500-1000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 88kDa 细胞定位 细胞核细胞浆 性状 Liquid 浓度 1mg/ml 免疫原 Recombinant human STAT3 Protein:9-265/770 亚型 IgG 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family

members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell

nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines

and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in

response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase

Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three

alternatively spliced transcript variants encoding distinct isoforms have been described. Gene Symbol: APRF; FLJ20882; HIES;

MGC16063.