货品编号： Bioss.bsm-33323M 品 牌： Bioss 品 名：Anti-Beclin 1Bcl-2同源结构域蛋白单克隆抗体 规 格： 100ul 研究领域 肿瘤免疫学神经生物学细胞凋亡 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 7B12 交叉反应 Human,Mouse,Rat, 产品应用 WB=1:500-1000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 50kDa 细胞定位 细胞浆细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human Beclin 1: 亚型 IgG 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function.

Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation,

survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated

in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21

that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved

52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.