货品编号： Bioss.bsm-33319M-100ul 品 牌： Bioss 品 名：Anti-PTEN肿瘤抑制基因PTEN单克隆抗体 规 格： 100ul 研究领域 肿瘤细胞生物细胞周期蛋白激酶和磷酸酶表观遗传学 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 4D9 交叉反应 Human, 产品应用 WB=1:500-2000IHC-P=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 44kDa 细胞定位 细胞核细胞浆 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human PTEN: 亚型 IgG 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

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产品介绍 Potential tumor suppressor. Acts as a phosphoinositide3-phosphatase by regulating PtdIns (3,4,5)P3 levels. Involved in

regulation of the AKT1 signaling pathway. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation.

The PTEN/MMAC1 discovers the first to have the suppress of the phosphoric acid enzyme activity cancer gene currently.

The gene of PTEN locates the chromosome10q23 area, sending forth sex tumor and a few households cancers with the

variety to suffer from the comprehensive disease easilyrelevant.The activity that passes to repress the Akt regulates the

cell period, the cell ground rule decease and glues to connect.This text discussed PTEN structure, function and its correlationses,

the PTEN is in tumor repress function mechanism.