货品编号Bioss.bs-1668R

品牌Bioss

品名Anti-XBP1细胞核转录因子X盒结合蛋白抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Cow,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量29/40kDa

细胞定位细胞核 细胞浆 细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human XBP-1:51-150/261

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred

to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds

to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins

by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded

proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional

splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt

from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.

The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative

feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A

pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]