货品编号Bioss.bs-2016R

品牌Bioss

品名Anti-Integrin Alpha V + Beta 1整合素αVβ1抗体

规格100ul

研究领域细胞生物 信号转导 细胞膜受体 细胞粘附分子

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 Flow-Cyt=1μg /test （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量114kDa

细胞定位细胞浆 分泌型蛋白

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic Mixed peptides 915-948/1048(human Integrin αV)+ 21-70/798(human Integrin β1):

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits

have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion

and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response

and metastatic diffusion of tumor cells.

Integrin alpha 5 belongs to the integrin alpha chain family. It contains seven FG-GAP repeats.

Integrin beta 1 belongs to the integrin beta chain family. It contains one VWFA domain.

Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands.

In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in

Kaposi's sarcoma lesions.