货品编号： bioss.bs-4593R-10ul 品 牌：bioss 品 名：Rabbit Anti-MMP9 antibody 规 格： 10ul 研究领域 肿瘤细胞生物免疫学神经生物学信号转导转录调节因子合成与降解 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Chicken,Dog,Pig,Horse,Rabbit,Sheep, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 78kDa 细胞定位 细胞外基质分泌型蛋白 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human MMP9:151-250/707 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍 All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The

ECM is constantly being remodeled and constant communication is maintained between cells through this matrix.

Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions.

MMPs are Zn(2+) binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated

in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes

are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix

metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor

genes.

Function: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone

osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three

quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.