货品编号：Bioss.bs-12414R

品牌：Bioss

品名：缪勒激素2型受体抗体

规格：100ul

研究领域干细胞 生长因子和激素 激酶和磷酸酶 细胞表面分子

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, (predicted: Mouse, Rat, Dog, Pig, Horse, )

产品应用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量61kDa

细胞定位细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human MISRII/AMHR2:21-120/573 <Extracellular>

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍MISR II is a 573 amino acid protein encoded by the human gene AMHR2. MISR II belongs to the protein kinase

superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily and contains one protein kinase domain.

Upon ligand binding, MISR II forms a receptor complex consisting of two type II and two type I transmembrane

serine/threonine kinases. These type II receptors phospho-rylate and activate type I receptors which autophosphorylate,

then bind and activate Smad transcriptional regulators. MISR II also acts as a receptor for anti-Muellerian hormone.

Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2). PMDS-2 is a form of male

pseudo-hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.