Bioss.bs-20658R Rabbit Anti-FSH receptor antibody 50ulBioss-耗材-金山科研平台 Thermo Fisher官网Nunc、QSP、Nalgene、Invitrogen、Gibco耗材试剂授权一级代理

Bioss.bs-20658R Rabbit Anti-FSH receptor antibody 50ulBioss

货品编号： Bioss.bs-20658R

品牌： Bioss

品名： Rabbit Anti-FSH receptor antibody

规格： 50ul

产品编号	bs-20658R
英文名称	FSH receptor
中文名称	促卵泡刺激素受体抗体
别名	Follicle-stimulating hormone receptor precursor; Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follitropin receptor; FSHRO; LGR1; ODG1; Follicle-stimulating hormone receptor; FSH-R; FSH R; Fshr; FSHR_HUMAN; MGC141667; MGC141668; ovarian dysgenesis 1.
	Specific References(3)\|bs-20658R has been referenced in 3 publications.[IF=5.108]Yang Z et al. ApilotstudyonpolycysticovariansyndromecausedbyneonatalexposuretotributyltinandbisphenolA inrats. Chemosphere.2019 Sep;231:151-160.WB;Rat.PubMed:31129395[IF=2.589]Zhou Z et al. Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system. Reprod Biol Endocrinol.2019 Jan 22;17(1):13.IHC-P;Rat.PubMed:30670046[IF=1.36]Wang, Junjie, et al. "Seasonal expression of luteinizing hormone receptor and follicle stimulating hormone receptor in testes of the wild ground squirrels (Citellus dauricus Brandt)." Acta Histochemica (2017).WB;Other Species.PubMed:28912046
研究领域	细胞生物发育生物学信号转导
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,Mouse,Rat, (predicted: Dog,Pig,Cow,Horse,Sheep,)
产品应用	WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1ug/TestIF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
分子量	78kDa
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human FSH receptor:21-100/695<Extracellular>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]Function:Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.Subunit:Interacts with ARRB2.Subcellular Location:Cell membrane; Multi-pass membrane protein.Tissue Specificity:Sertoli cells and ovarian granulosa cells.DISEASE:Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.Similarity:Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.Contains 9 LRR (leucine-rich) repeats.Contains 1 LRRNT domain.SWISS:P23945Gene ID:2492Database links: Entrez Gene: 281172Cow Entrez Gene: 100861291Goat Entrez Gene: 2492Human Entrez Gene: 14309Mouse Entrez Gene: 397679Pig Entrez Gene: 25449Rat Entrez Gene: 443299Sheep Omim: 136435Human SwissProt: P35376Cow SwissProt: P23945Human SwissProt: P35378Mouse SwissProt: P49059Pig SwissProt: P20395Rat SwissProt: P35379Sheep Unigene: 1428Human Unigene: 57155Mouse Unigene: 162843Rat Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.FSHR属于G蛋白偶联受体超家族中的糖蛋白亚家族成员，跨膜蛋白。人类的FSHR是由695个氨基酸组成的一条肽链，主要分布于睾丸支持细胞和卵巢颗粒细胞
产品图片	Sample: Ovary (mouse) Lysate at 40 ugPrimary: Anti- FSH receptor (bs-20658R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 78kDObserved band size: 78kDParaformaldehyde-fixed, paraffin embedded (rat ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FSH receptor ) Polyclonal Antibody, Unconjugated (bs-20658R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining.Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CBFb) Polyclonal Antibody, Unconjugated (bs-20658R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Blank control (blue line): MCF7 (fixed with 70% methanol overnight at 4℃).Primary Antibody (green line): Rabbit Anti-FSH receptor antibody (bs-20658R) ,Dilution: 0.2μg /10^6 cells;Isotype Control Antibody (orange line): Rabbit IgG .Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE,Dilution: 1μg /test.

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Bioss.bs-20658R Rabbit Anti-FSH receptor antibody 50ulBioss

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