货品编号： Sigma.M3262-100MG 品牌：Sigma 品名：N-METHYL-D-ASPARTIC ACID 规格：100MG

Application N-Methyl-D-aspartic acid has been used to induce N-methyl-d-aspartic acid (NMDA) toxicity, cultures of retinal cells were

supplemented with NMDA.[1][4]

Biochem/physiol Actions Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in

long-term potentiation, ischemia, and epilepsy.

N-Methyl-D-aspartic acid (NMDA) plays a crucial role in release of luteinizing hormone and PRL (prolactin) in the pituitary gland

and GnRH (gonadotropin releasing hormone) in the hypothalamus.[2][3] It acts as a specific agonist for NMDA type glutamate

receptors.[3]

Features and Benefits This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically

annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

General description N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present

at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-

dependent enzyme also referred to as NMDA synthase.