货品编号： signalchem.B10-12CH-05 品牌：signalchem 品名：BTK (C481S), Active 规格：5ug 产品描述：

Description: Recombinant full-length human BTK (C481S) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.

Species: Human

Tag: His tag

Expression System: Sf9 insect cells using baculovirus

Sequence: Full Length (C481S)

Genbank Number: NM_000061

Specific Activity : Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.

torage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and

store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Kinase Assay, Western Blot

Molecular Weight : ~75kDa

Gene Aliases : AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK

Formulation : 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Scientific Background : BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK

interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors (1).Defects in

the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells

and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer,

anti-inflammatory and anti-viral agents as well as other treatments (2).