产品描述： background: Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the

active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing

the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive

cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to

the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is

strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.

Function: Thought to be required for maintaining cell proliferation.

Subcellular Location: Nucleus. Chromosome. Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also

detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all

chromosomes.

Similarity: Contains 1 FHA domain.