产品描述： background: Hic-5 contains four LIM motifs and seven zinc finger domains. In the cell, Hic-5 localizes to the nuclear matrix and

focal adhesion complexes where the LIM domains mediate the interactions of Hic-5 with focal adhesions. Known

also as transforming factor beta 1 induced transcript 1, Hic-5 shares extensive homology with the structural protein

paxillin, which is involved in the regulation of focal adhesion dynamics. Hic-5 inhibits integrin-mediated cell spreading

on Fibronectin by out competing paxillin for focal adhesion kinase and thereby preventing downstream signal

transduction. Increased expression of Hic-5 leads to cellular senescence in developing fibroblasts. During myogenesis,

expression of Hic-5 blocks differentiation and induces apoptosis of developing myoblasts. The gene encoding human

Hic-5 maps to chromosome 16.

Function: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in

the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB

signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity.

In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone

receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and

senescence. May have a zinc-dependent DNA-binding activity.