货品编号： thermo.17-5773-82 品牌：thermo 品名：FOXP3 Monoclonal Antibody (FJK-16s), APC, eBioscience™

规格：100ug

产品描述： Product Specific Information Description: The FJK-16s antibody reacts with mouse, rat, dog, porcine, bovine and cat Foxp3 also known as FORKHEAD

BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55

kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene

defective in 'scurfy' (sf) mice. Constitutive high expression of foxP3 mRNA has been shown in CD4+CD25+ regulatory T

cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells.

Immunoblotting with FJK-16s antibody has mapped the epitope to amino acids 75-125 of the mouse Foxp3 protein. In the

human, this region has been shown to be alternatively spliced at the mRNA level. Both the alternatively-spliced and non-

spliced isoforms are present in the CD4+CD25+ subset of lymphocytes. Preliminary RT-PCR experiments have not revealed

this alternatively-spliced isoform in mouse splenocytes, suggesting different gene regulation in the mouse and human.