产品描述： background: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have

six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within

specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the

protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by

its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein

A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in

this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with

other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are

expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Function: Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release

and chemotaxis.