产品描述： background: The claudin superfamily consists of structurally related proteins that are important structural and functional components of

tight junctions. Claudin-2, also known as CLDN2 or SP82, is a 230 amino acid multi-pass membrane protein that localizes

to the cell junctions and belongs to the claudin superfamily. Able to form homopolymers of heteropolymers with other claudin

family members, claudin-2 plays an essential role in mediating calcium-independent cell-adhesion activity that is necessary

for tight junction-specific obliteration of the intercellular space. Overexpression of claudin-2 is associated with a variety of

diseases, including lung cancer, colorectal cancer, gastrointestinal carcinomas and inflammatory bowel disease, further

affirming the importance of claudin-2 in cell adhesion. The gene encoding claudin-2 maps to human chromosome X, which

contains nearly 153 million base pairs and houses over 1,000 genes.