货品编号： peprotech.100-11-100 品牌：peprotech 品名：Recombinant Human IGF-I 规格：100ug

产品描述： Description: The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types,

including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues

produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The

IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression

is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the

tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs

are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.

Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular

disulfide bonds. The calculated molecular weight of Recombinant Human IGF-I is 7.6 kDa.