品牌： 博奥森

品名： Anti

规格： 50ul/支

产品描述：

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role

in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and

share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are

expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective

immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like

receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain

of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

Subunit:

Binds TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains.

Subcellular Location:

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein.