规格：100ul

研究领域 心血管免疫学细胞膜受体 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat, 产品应用 WB=1:500-2000ELISA=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 121kDa 细胞定位 细胞膜分泌型蛋白 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human CD163:551-650/1156<Extracellular> 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍

CD163 is a 130 kDa membrane glycoprotein. It is a member of the scavenger receptor cysteine-rich superfamily and

is a receptor for the hemoglobin-haptoglobin complex. CD163 is expressed exclusively on the cell surface of human

monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14

positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163

is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol

myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant.

Function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages

and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling

of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes

in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin

of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype.Induces a cascade of intracellular

signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.

Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.