品牌： Bioss

品名： Anti-CREB-1环腺苷酸应答元件结合蛋白抗体

规格： 100ul

研究领域：信号转导

抗体来源：Mouse

克隆类型：Polyclonal

交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,

产品应用：WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量：37kDa

细胞定位：细胞核

性 状：Liquid

浓 度：1mg/ml

免 疫 原：KLH conjugated synthetic peptide derived from human CREB-1:101-150/341

亚 型：IgG

纯化方法：affinity purified by Protein A

储 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed：PubMed

产品介绍：Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription

factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety

of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and

neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation

occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will

bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription

factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to

CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB

knock out mice show diminished learning ability.