品牌： Bioss

品名： Anti-phospho-CREB-1 (Ser133)磷酸化CREB-1抗体

规格： 100ul

研究领域：免疫学 染色质和核信号 信号转导 转录调节因子

抗体来源：Rabbit

克隆类型：Polyclonal

交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,

产品应用：WB=1:500-2000 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量：37kDa

细胞定位：细胞核

性 状：Liquid

浓 度：1mg/ml

免 疫 原：KLH conjugated Synthesised phosphopeptide derived from human CREB-1 around the phosphorylation site of Ser133:RP(p-S)YR

亚 型：IgG

纯化方法：affinity purified by Protein A

储 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed：PubMed

产品介绍：The ATF/CREB family consists of transcription factors that function through binding to the cAMP

responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this

gene family include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-4. these transcription factors share

highly-related COOH terminal leucine zipper demerization and basic DNA bindings but are highly divergent

in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric

form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family and with members

of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A-mediated CREB

phosphorylation results in its binding to a 265kDa nuclear protein designated CBP (CREB-binding protein),

which may reprecent a CREB co-activator.