货品编号： Bioss.bs-0049R-100ul
品牌： Bioss
品名： Anti-Caspase-9活化半胱胺酸蛋白酶蛋白-9抗体
规格： 100ul
研究领域：肿瘤细胞生物神经生物学信号转导细胞凋亡
抗体来源：Rabbit 克隆类型：Polyclonal 交叉反应：Human,Mouse,Rat,Dog,Cow, 产品应用：WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1μg/testICC=1:100IF=1:100-500（石蜡切片需做抗原修复） notyettestedinotherapplications. optimaldilutions/concentrationsshouldbedeterminedbytheenduser. 分子量：35/50kDa 细胞定位：细胞浆 性状：Liquid 浓度：1mg/ml 免疫原：KLHconjugatedsyntheticpeptidederivedfromhumanCaspase-9subunitp35:11-120/416 亚型：IgG 纯化方法：affinitypurifiedbyProteinA 储存液：0.01MTBS(pH7.4)with1%BSA,0.03%Proclin300and50%Glycerol. 保存条件：Shippedat4℃.Storeat-20°Cforoneyear.Avoidrepeatedfreeze/thawcycles. PubMed：PubMed 产品介绍：Caspase9(alsoknownasICElikeapoptoticprotease6(ICELAP6),apoptoticproteaseMch6,andapoptoticprotease
activatingfactor3(Apaf3))isamemberofthepeptidasefamilyC14thatcontainsaCARDdomain.Thiscaspaseisactiveasa
heterotetramerandhasbeenreportedtohavetwoisoforms.ProCaspase9hasbeenreportedtobeapproximately47kD.This
caspaseispresentinthecytosoland,uponactivation,translocatestothemitochondria.Caspase9isinvolvedinthecaspase
activationcascaderesponsibleforapoptosisexecutionandcleaves/activatesCaspase3andCaspase6.Caspase9isinhibited
bythedominantnegativeisoform,BclXL,cIAP1,cIAP2,XIAP,andLivin.Thiscaspasebecomesactivatedwhenrecruitedto
Apaf1tochromeccomplex,andfollowingcleavagebyApaf1,granzymeB,Caspase3,possiblyCaspase8andCaspase10
intolargep37andsmallp10subunits.Caspase9intereactswithBIRC7andhasbeenshowntocleavePARPandvimentin.
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