货品编号： Bioss.bs-0174R-100ul

品牌： Bioss

品名： Anti-Estrogen Receptor alpha + beta雌激素受体α/β抗体

规格： 100ul

研究领域肿瘤 染色质和核信号 信号转导 内分泌病 肿瘤细胞生物标志物 表观遗传学

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Pig,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量66kDa

细胞定位细胞核 细胞浆 细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Estradiol Receptor alpha + beta:201-300/595

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The estrogen receptor (ER) is a 66 kDa protein that mediates the actions of estrogens in estrogen

responsive tissues. It is a member of a large superfamily of nuclear hormone receptors that function as ligand

activated transcription factors. The ER gene consists of more than 140 kb of genomic DNA divided into 8 exons.

These translate into a protein with six functionally discrete domains, labeled A through F. A second form of the estrogen

receptor, ER beta has recently been described. The ER is an important regulator of growth and differentiation in the

mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti estrogen

(e.g. tamoxifen) therapy