货品编号Bioss.bs-0566R

品牌Bioss

品名Anti-MADH7/Smad7Smad7抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Pig, Cow,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量46kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Smad7:1-100/426

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2.

Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta

receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1.

Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility

to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have

been found for this gene. [provided by RefSeq, Jun 2010]