货品编号Bioss.bs-10129R

品牌Bioss

品名Anti-CDKN1A/P21p21蛋白抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量18kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human P21:21-100/164

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the

activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1.

The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein

mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein

can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a

regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically

cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in

the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an

identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified.

The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and

Cdk6 specifically.