货品编号Bioss.bs-10446R

品牌Bioss

品名Anti-HPV16 E7人类乳头状瘤病毒16-E7抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, HPV16

产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量60kDa

细胞定位细胞核

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human HPV16 E7:21-98/98

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association

with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among

the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational

analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV

transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate

with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do

the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.