货品编号Bioss.bs-1658R

品牌Bioss

品名Anti-phospho-STAT3 (Tyr705)磷酸化信号转导和转录激活因子3抗体

规格100ul

研究领域肿瘤 心血管 细胞生物 免疫学 信号转导 干细胞 细胞凋亡 转录调节因子 表观遗传学

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量85kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated Synthesised phosphopeptide derived from human STAT3 around the phosphorylation site of Tyr705:AP(p-Y)LK

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors,

STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers

that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation

in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates

the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such

as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein.

PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem

autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants

encoding distinct isoforms. [provided by RefSeq, Sep 2015]