货品编号： Bioss.bs-4605R-100ul 品 牌： Bioss 品 名： Anti-MMP2基质金属蛋白酶-2抗体 规 格： 100ul 研究领域 肿瘤免疫学神经生物学合成与降解 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=2ug/TestICC=1:100IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 24/62kDa 细胞定位 细胞核细胞浆细胞膜分泌型蛋白 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human MMP-2 PEX:561-660/660 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

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产品介绍 This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving

components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase

A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V

collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be

activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-

domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown,

regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-

Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by

RefSeq, Oct 2014]